Epigenetic profiling of young and aged spermatogonial stem cells (RRBS)
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https://www.ncbi.nlm.nih.gov/sra/SRP301292
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资源简介：
Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. Aged SSCs exhibited gene body hypomethylation, which is accompanied by an elevated 5hmC level. Overall design: We separated stem cells (Oct4-GFP+/KIT-) and their immediate proliferating daughter cells (Oct4-GFP+/KIT+) using FACS from adult (6-8 months) and aged mice (15-18 months), which were subjected to RRBS and oxRRBS analysis.
创建时间：
2021-09-15
