Pancreatic Cancer Organoid Profiling

This study generated a collection of patient-derived pancreatic normal and cancer organoids and it was sequenced using Whole Genome Sequencing (WGS), Whole Exome Sequencing (WXS) and RNA-Seq as well as matched tumor and normal tissue if available. The study provides a valuable resource for pancreatic cancer researchers. The dataset contains open RNA-Seq Gene Expression Quantification data and controlled WGS/WXS/RNA-Seq Aligned Reads, WXS Annotated Somatic Mutation, WXS Raw Somatic Mutation, and RNA-Seq Splice Junction Quantification.

本研究构建了患者来源的胰腺正常类器官与癌性类器官集合，并针对该集合开展了全基因组测序（Whole Genome Sequencing, WGS）、全外显子组测序（Whole Exome Sequencing, WXS）与RNA测序（RNA-Seq）；若可获取匹配的肿瘤与正常组织，同步完成了对应测序。本数据集为胰腺癌研究人员提供了极具价值的研究资源。该数据集包含开放获取的RNA-Seq基因表达定量数据，以及受控访问的WGS/WXS/RNA-Seq比对读段数据、WXS注释体细胞突变数据、WXS原始体细胞突变数据与RNA-Seq剪接接头定量数据。

搜集汇总

背景与挑战

背景概述

该数据集包含患者来源的胰腺正常和癌器官组织的全基因组测序（WGS）、全外显子测序（WXS）和RNA-Seq数据，为胰腺癌研究提供了宝贵资源。数据集包括开放的RNA-Seq基因表达定量数据和受控的WGS/WXS/RNA-Seq对齐读取、WXS注释体细胞突变、WXS原始体细胞突变以及RNA-Seq剪接连接定量数据。