Transcriptional down-regulation of major histocompatibility complex as a possible pathogenesis for Meniere's disease

This study aimed to determine the underlying pathogenesis of Meniere's disease (MD) using transcriptome analysis Total RNAs were extracted from peripheral blood mononuclear cells of 9 patients with MD and 9 normal controls. Using the Affymetrix Human Clariom S Assay, the differentially expressed genes (DEGs) between MD and normal control samples were screened by the cut-off criteria (|fold changes| > 2 and adjusted p-value < 0.05). Functional enrichment analysis for DEGs was performed using Gene Ontology (GO).