The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Name: The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
Creator: Good, Levi; Sun, Suya; Supnet, Charlene; Liu, Jie; Zhang, Hua; Bezprozvanny, Ilya; Popugaeva, Elena
Published: 2025-10-06 00:00:00
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Taylor & Francis Group2025-10-06 更新2026-04-16 收录

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https://tandf.figshare.com/articles/dataset/The_role_of_ryanodine_receptor_type_3_in_a_mouse_model_of_Alzheimer_disease/30286801/1

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资源简介：

Dysregulated endoplasmic reticulum (ER) calcium (Ca<sup>2+</sup>) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca<sup>2+</sup> release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models. The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology.

提供机构：

Good, Levi; Sun, Suya; Supnet, Charlene; Liu, Jie; Zhang, Hua; Bezprozvanny, Ilya; Popugaeva, Elena

创建时间：

2025-10-06