HORDB data

Hormone peptides are secreted by endocrine cells to act on target cells. They serve as signal molecules and play vital roles in the regulation of metabolism, growth and differentiation, etc. They present a unique group of drugs that mimics natural pathways, especially as supplement therapies where deficient on endogenous levels. The first clinically used hormone peptide, insulin, has been used in diabetes for about one hundred years. With the tremendous progress in protein/peptide detection and quantification procedures, the number of hormone peptides has increased dramatically. We constructed HORDB(hordb.cpu-bioinfor.org), a comprehensive database of hormone peptides. The database holds 6025 entries,including 5729 hormone peptides, 40 peptides drugs and 256 marketed preparations of these drugs. Each item has detailed notes, containing basic information, sequence, structure, activity, physics, and literature. We also added IC₅₀, EC₅₀, ED₅₀ and information about whether to cross the blood-brain barrier into the activity information annotation. Peptides with a PDB structure display their structure in the database. In addition, HOROB integrates search and sequence analysis to facilitate user browsing and data analysis.