Genome-wide gene expression pattern of E47 KO versus WT HSCs from primary and secondary recipient mice were analysis using Agilent one-color micro-array analysis. Overall design: Two replicates from 4

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Identification of E47 targets

In maturing T-lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as β selection. To examine how E47 r

NIAID Data Ecosystem20

Transcription profiling of HSCs from SYCNRIP WT and KO mice. Transcription profiling of HSCs from SYCNRIP WT and KO mice

SYNCRIP depletion results in HSCs losing their self renewal abilities. Next generation sequencing was conducted in SYNCRIP WT and KO HSCs to investigate the transcriptional changes that occur, and res

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