Multiple sequence alignment, AF3 structures, and Origin plots of human NOTCH3 with 113 mammals using CLUSTAL-Omega.
收藏DataCite Commons2025-09-27 更新2026-04-25 收录
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https://figshare.com/articles/dataset/Multiple_sequence_alignment_AF3_structures_and_Origin_plots_of_human_NOTCH3_with_113_mammals_using_CLUSTAL-Omega_/30223750
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NOTCH3 is a highly conserved transmembrane receptor implicated in CADASIL, a hereditary small vessel disease driven by mutations in its extracellular EGF-like repeats. The mechanism by which these mutations cause pathology remains unclear. We present the first large-scale comparative bioinformatic analysis of NOTCH3 across 113 mammalian species, uncovering three novel insights.
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figshare
创建时间：
2025-09-27
