Th1-Th2 Signaling

The Th1/Th2 Signaling network depicts the causal mechanisms that are activated in T helper 1 (Th1) cells following engagement with macrophages including pathways related to the STAT4 and T-bet transcription factors leading to Th1-specific differentiation as well as the causal mechanisms that are activated in T helper 2 (Th2) cells following engagement primarily with B-cells including pathways related to the STAT6 and GATA transcription factors leading to Th2-specific differentiation. The network also encompasses the chemokine pathways involved in mediating T-cell recruitment to compromised lung tissue during COPD development and Th1-produced cytokines that activate cytotoxic T-cells, natural killer cells and macrophages and Th2-produced cytokines that activate B cells, eosinophils and suppress macrophage activation.\u003c/p\u003e\n\u003ch2\u003eJamboree Review Focus\u003c/h2\u003e\n\u003cp\u003eLung memory CD4+ T cell signaling and T-helper cell interaction with other immune cells including T-helper and B cell CD40L-CD40 interaction and NK and Tc activation by Th cells. Reviewed during Jamboree2014. Reviewed during Jamboree2015