FLUID SHEAR STRESS-INDUCED MECHANOTRANSDUCTION IN MYOBLASTS: DOES IT DEPEND ON GLYCOCALYX?

Muscle stem cells (MuSCs) are requisite for skeletal muscle regeneration and homeostasis. Mechanically loaded MuSCs within their native niche undergo tensile and shear deformations, but how MuSCs sense mechanical stimuli and translate these into biochemical signals regulating function and fate is still poorly understood. The glycocalyx is known to affect the response of endothelial cells, bone cells, and myotubes to fluid shear stress (FSS), but whether it plays a role in the mechanoresponse of MuSCs is unknown. The data published here is the research output on the role of glycocalyx in mechanotransduction. <br>