Putative Cdk5-dependent phosphorylation sites downregulated in Cdk5−/− brains.

In bold type phosphorylated sites previously described in other mouse brain phosphoproteomic studies but lacking an assigned protein kinase responsible for such a phosphorylation.a: phosphorylated by Cdk5,b: phosphorylated by Cdk1;c: phosphorylated by Cdk2.PSSM scores determined as Borquez et al, 2013. NetphosK scores calculated using public protein prediction tool.Asterisks (*) indicated Cdk5 is the best kinase for a given site.Candidates validated in the present study are presented in italics type.