MEX3A Promotes Nasopharyngeal Carcinoma Progression by Regulating Alternative Splicing of Cell Cycle-Related Genes

Based on public databases, transcriptome data from NPC (GSE68799) and head and neck cancer (TCGA, HNSC) patients were downloaded, and the differentially expressed RBP-MEX3A was identified through bioinformatic analysis. An MEX3A overexpression model was subsequently established in C666-1 cells. Cell proliferation was assessed using the CCK-8 assay, and apoptosis was analyzed by flow cytometry. Transcriptome sequencing was performed to systematically identify differentially expressed genes (DEGs) and alternative splicing (AS) events induced by MEX3A overexpression.