Lee2010_ThrombinActivation_OneForm
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下载链接：
https://www.omicsdi.org/dataset/biomodels/BIOMD0000000364
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资源简介：
Chang Jun Lee, Sangwook Wu, Changsun Eun & Lee G. Pedersen. A revisit to the one form kinetic model of prothrombinase. Biophysical Chemistry 149, 1-2 (2010).
Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production.
创建时间：
2024-09-02
