DUSP11-mediated Control of 5’-Triphosphate RNA Regulates RIG-I Sensitivity. DUSP11-mediated Control of 5’-Triphosphate RNA Regulates RIG-I Sensitivity

Mice lacking DUSP11 display enhanced interferon signaling signature Overall design: RNA extracted from liver (n=24) or spleen (n=6) of wild-type (n=15) and DUSP11-deficient (n=15) mice subjected to immune-stimulatory 5'-ppp RNA treatment (n=12 liver, 8 male/4 female), mock treatment (n=6 liver, 2 male/4 female; n=6 spleen, 2 male/4 female), or untreated (n=6 liver, 4 male/2 female). Mice were age/sex pair-matched within each treatment.