Agent-based models predict emergent behavior of heterogeneous cell populations in dynamic microenvironments: POPULATION HETEROGENEITY (3/5)

Data and results for `POPULATION HETEROGENEITY` simulations.

Simulations of all possible combinations of four populations (X, A, B, C) under colony and tissue context with different levels of parameter heterogeneity (0, 0.1, 0.2, 0.3, 0.4, and 0.5). For tissue context, the healthy cell populations also varies parameter heterogeneity independent of the cancerous cell populations. Each condition is run for 15 days (21600 ticks) with 20 replicates (random seeds 0 - 19). Cells are introduced to the center of the constant source environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The data.param folder contains .tar.xz compressed replicate sets for .PARAM output. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[populations]_[population heterogeneity]_[background heterogeneity]

- [context]
- C = colony context, cancerous cell populations only
- CH = tissue context, cancerous cell populations and healthy cells
- [populations]
- X = cancerous cell population with basal parameters
- A = cancerous cell population with max_height x 1.5
- B = cancerous cell population with meta_pref x 1.5
- C = cancerous cell population with migra_threshold x 0.5
- [population heterogeneity]
- ## = heterogeneity value for cancerous cell populations (##/10)
- [background heterogeneity]
- ## = heterogeneity value for healthy cell population (##/10)

Additional data and results for this simulation set available at:

- doi: 10.17632/bk9s769t3t
- doi: 10.17632/mjpcm5my8z
- doi: 10.17632/ynzsfdswjz
- doi: 10.17632/p46dwfyvzg

本数据集包含针对`种群异质性`模拟的数据和结果。该模拟涵盖了四种种群（X、A、B、C）在殖民地和组织背景下的所有可能组合，以及不同参数异质性水平（0、0.1、0.2、0.3、0.4和0.5）。在组织背景下，健康细胞种群也具有独立的参数异质性，不受癌细胞种群的影响。每个条件均运行15天（21600个时间单位），进行20次重复（随机种子0-19）。细胞在延迟1天后被引入恒定源环境的中心。每0.5天（720个时间单位）进行一次快照。数据文件夹包含.tar.xz压缩的重复集。data.param文件夹包含.tar.xz压缩的重复集，用于.PARAM输出。结果文件夹包含解析为数组的.pkl文件。模拟标签为：[背景]_[种群]_[种群异质性]_[背景异质性]

- [背景]
- C = 殖民地背景，仅包含癌细胞种群
- CH = 组织背景，包含癌细胞种群和健康细胞
- [种群]
- X = 基础参数的癌细胞种群
- A = 高度参数为max_height x 1.5的癌细胞种群
- B = meta_pref参数为1.5倍的癌细胞种群
- C = 迁移阈值参数为0.5倍的癌细胞种群
- [种群异质性]
- ## = 癌细胞种群的异质性值（##/10）
- [背景异质性]
- ## = 健康细胞种群的异质性值（##/10）

此外，本模拟集的额外数据和结果可在以下链接获取：
- doi: 10.17632/bk9s769t3t
- doi: 10.17632/mjpcm5my8z
- doi: 10.17632/ynzsfdswjz
- doi: 10.17632/p46dwfyvzg