Environmental chemicals from the Comparative Toxicogenomics Database linked to autism disease pathways

We identify numerous chemical stressors that intersect with the individual events of the autism AOP, including bisphenol compounds, per/polyfluoroalkyl substances, pesticides, metals, and air pollutants, suggesting a wide range of environmental factors that could synergize to potentially affect autism. By integrating additional CTD curated content for three autism-associated chemicals (bisphenol A, particulate matter, and valproic acid), we discover other mechanisms that can be used to help refine or expand this AOP or create an entirely new pathway for autism.