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Long Non-Coding RNA LEENE Promotes Angiogenesis and Ischemic Recovery (RNA-Seq I)

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE205279
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Vascular endothelial cells play a pivotal role in whole-body homeostasis. To test the function of human long non-coding RNA LEENE in Human umbilical vein endothelial cells (HUVEC), we inhibited LEENE by using a previously validated locked nucleic acid (LNA) GapmeR under pulsatile flow which mimics the physiological state and is characterized by elevated LEENE levels. PolyA-enriched RNA-seq was performed to examine the LEENE-regulated gene expression. PolyA-enriched RNA-seq in HUVEC with LEENE knockdown by LNA
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2023-02-09
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