FAIRsharing record for: MiST 4.0: Microbial Signal Transduction database

This FAIRsharing record describes: Signal transduction systems in bacteria and archaea link environmental stimuli to specific adaptive cellular responses. They control gene expression, motility, biofilm formation, development and other processes that are vital to survival. The microbial signal transduction (MiST) database is an online resource that stores tens of thousands of genomes and allows users to explore their signal transduction profiles, analyze genomes in bulk using the database application programming interface (API) and make testable hypotheses about the functions of newly identified signaling systems. However, signal transduction in metagenomes remained completely unexplored. To lay the foundation for research in metagenomic signal transduction, we have prepared a new release of the MiST database, MiST 4.0, which features over 10 000 metagenome-assembled genomes (MAGs), a scaled representation of proteins and detailed BioSample information. In addition, several thousand new genomes have been processed and added to the database, bringing the total to over 202,000 genomes now available in MiST. A new interface has been developed that allows users to seamlessly switch between genomes and MAGs. Starting from MiST 4.0, the database incorporates updates to the NCBI taxonomy reflecting the inclusion of the rank "phylum" in the International Code of Nomenclature for Prokaryotes, which involved changes to 42 taxa.

MiST 4.0 is freely accessible at https://mistdb.com; genomes and MAGs can also be explored using the API available on the same page.