Transcriptome of human neck-derived immortalized white preadipocyte cell lines

White adipose tissue is a major site of energy storage and plays a noteworthy role in physiological homeostasis and metabolic disease. Different types of fat have been demonstrated to exhibit distinct metabolic and inflammatory profiles and are differentially associated with disease risk. It is unclear whether these differences are intrinsic to the pre-differentiated stage. We address this challenging question using RNA sequencing on clonally-expanded human white preadipocyte cell lines. We have identified differences in gene expression that are separate from the process of browning and beiging. Overall design: RNA-seq profiling of clonally-expanded human white preadipocyte cell lines.