microRNA signature in b-cell lymphomas and control human B cells from fresh tonsils. Homo sapiens

147 B-cell lymphomas were studies for miRNA expression miRNA profiling of control human B cell populations Comparison of miRNA expression profiles of naive B cells (CD19+ IgD+ CD27-) from 3 individuals and germinal center B cells (CD10+ CD19+) from 4 individuals Overall design: 147 B-cell lymphomas were hybridized on a human miRNA one-color platform containing probes for 470 human miRNAs. Each lymphoma type was compared to all set of NHLs. Burkitt Lymphoma was also directly compared to DLBCL miRNA expression signature is different in human naive B cells compared to Germinal Center B cells