Comparison of ISHDSF rank and hypothesis based gene selection results to random gene selection in schizophrenia CATIE and GAIN GWAS datasets.

aCategory 1: genes are both highly ranked and involved in neurodevelopment. Category 2: genes are exclusive to neurodevelopment. Category 3: genes are exclusively highly ranked (see details in text).
bWe performed simulations by four methods: 1) based on the count of SNPs, 2) based on the minimum p-value, 3) based on the number of SNPs with p<0.05, and 4) based on the number of SNPs with p<0.005.
c100,000 simulations (see text).
dTo reduce bias, simulations were filtered with top 500 or 10,000 SNPs being used (see Materials and Methods).