Self-Organized Generation Of Hepatic Cord Like Organoids (HCLOs) With Zonal Diversity (RNA-seq). Self-Organized Generation Of Hepatic Cord Like Organoids (HCLOs) With Zonal Diversity (RNA-seq)

To investigate the efect of extracellular bilirubin and intracellular ascorbate on the development of zonal hepatocytes in human liver organoids Overall design: We performed RNAseq on control HLOs compared to HLOs treated with extracellular bilirubin and genetically modified mGULO HLOs that express intracellular ascorbate