Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population

Background: Gestational diabetes mellitus (GDM) is an endocrine disorder that occurs easily in women during pregnancy. HLA-DQA1/DQB1 genes play a crucial role in the regulation of the human immune and endocrine systems, potentially influencing the pathogenesis of GDM.
Objective: To explore the associations between single nucleotide polymorphisms (SNPs) in HLA-DQA1/DQB1 genes and the risk of GDM.
, Seven functional SNPs of HLA-DQA1/DQB1 genes were selected and genotyped in 523 GDM patients and 638 normal pregnant women. The odds ratio (OR) and its corresponding 95% confidence interval (CI) were utilized to assess the association between candidate SNPs and the risk of GDM. And then, false positive report probability (FPRP), multifactor dimensionality reduction (MDR) and haplotype analysis were employed to validate the statistically significant associations between studied SNPs and GDM risk.
, Data from: Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population
Descriptions
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This dataset includes 523 gestational diabetes mellitus (GDM) patients and 638 healthy pregnancies’ baseline information obtained from a unique questionnaire and medical records, and the genetic loci were genotyped by the Sequenom MassARRAY platform. Evaluate the relationship between certain genetic variations and the risk of GDM by integrating clinical, biochemical, and genetic data.

Subjects’ baseline data involve age, pre-BMI, systolic blood pressure (SBP, mmHg), diastolic blood pressure (DBP, mmHg), triglyceride (TG, mmol/L), total cholesterol (TC, mmol/L), high-density lipoprotein cholesterol (HDL-c, mmol/L), low-density lipoprotein cholesterol (LDL-c, mmol/L), fasting plasma glucose (FPG, mmol/L), oral glucose tolerance test 1h plasma glucose (1hPG, mmol/L), oral glucose tolerance test 2h plasma glucose (2hPG, mmol/L), g..., All participants were provided written informed consent. The personal identity information data of the subjects have all been anonymized.