Redox-Triggered α‑C–H Functionalization of Pyrrolidines: Synthesis of Unsymmetrically 2,5-Disubstituted Pyrrolidines
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下载链接：
https://figshare.com/articles/dataset/Redox_Triggered_C_H_Functionalization_of_Pyrrolidines_Synthesis_of_Unsymmetrically_2_5_Disubstituted_Pyrrolidines/2126347
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资源简介：
By using o-benzoquinone
as an internal oxidant,
the regio- and diastereoselective functionalization of the secondary
over the tertiary α-C–H bond of 2-substituted pyrrolidines
is first realized. Subsequent intermolecular addition of a nucleophile
to the generated N,O-acetal and
cleavage of the aromatic substituent leads to 2,5-disubstituted pyrrolidines.
创建时间：
2016-02-13
