Selected characteristics of swine in the control group (n = 6) and NASH diet group (n = 6) at baseline and at weeks 8, 16 and 24 of dietary intervention.

Phenotypic characteristics of the swine. Weight, blood pressure, and serum biochemistries at baseline and at the 8, 16, and 24 week time points. The NASH diet group weighed significantly more than the control group. Compared to the control group, the NASH diet group had significantly increased systolic and diastolic blood pressure at weeks 16 and 24. The NASH diet group displayed transaminase elevations after 16 weeks of feeding and a trend of increasing serum AST and ALT levels (p<0.1) was also observed. At week 24, serum AST, ALT, triglyceride levels in the NASH diet group were more than double those of control swine. While serum cholesterol progressively increased in the NASH diet group. At week 24, serum cholesterol in the NASH diet group was dramatically higher than in the control group.
§P is the p-value between NASH and control groups at the indicated time points.
*P is the P-value of within NASH group comparison between the indicated time points and baseline.
Selected characteristics of swine in the control group (n = 6) and NASH diet group (n = 6) at baseline and at weeks 8, 16 and 24 of dietary intervention.