Probiotics improve acute gastrointestinal dysfunction in patients undergoing cardiopulmonary bypass surgery

Acute gastrointestinal injury (AGI) after cardiopulmonary bypass (CPB) is one of the signs for poor prognosis. This study aimed to investigate the effect of preoperative probiotics supplementation on AGI. In this double-blind randomized controlled trial, patients undergoing heart valve replacement (HVR) with CPB were randomly assigned to receive either a probiotic (Lac group) or placebo (Placebo group). The probiotic was given daily, for seven days before surgery. We demonstrated that preoperative supplementation of probiotics can improve the recovery of patients after CPB surgery by preventing acute gastrointestinal injury. Cardiac Surgery Score, and the duration of CPB ≥ 132 min are independent risk factors for the occurrence of AGI. In contrast, probiotics is a preventive factor for the occurrence of AGI. There was gut microbiota imbalance in patients who underwent HVR with CPB. The 16s rRNA showed that there was a difference in gut microbiota between two groups.

急性胃肠道损伤（AGI）是心脏肺循环旁路（CPB）术后不良预后的一个显著标志。本研究旨在探讨术前益生菌补充对AGI的影响。在此双盲随机对照试验中，接受CPB下心脏瓣膜置换术（HVR）的患者被随机分配至接受益生菌（Lac组）或安慰剂（安慰剂组）。益生菌于手术前每日服用，连续七日。本研究证实，术前益生菌的补充可以通过预防急性胃肠道损伤来改善CPB术后患者的康复。心脏手术评分以及CPB持续时间≥132分钟是AGI发生的独立风险因素。相反，益生菌是预防AGI发生的保护因素。接受CPB下HVR的患者存在肠道菌群失衡。16s rRNA分析显示，两组患者的肠道菌群存在差异。