Ratios of phosphotyrosine to all phosphorylations within selected adaptor domains.

The number of phosphorylations within selected domains was analyzed by PhosphoSite Plus and the ratio of phosphotyrosine sites (pY) to all sites was calculated. The complete human proteome from the Uniprot database was chosen to calculate the number of tyrosines among human proteins. The complete sets of human proteins containing adaptor domains was selected using the Pfam database.Normalized relative enrichment of tyrosine phosphorylation shows ratio of percentage of pY to percentage of pY in human proteome normalized to number of tyrosines.