Eif2ak3
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资源简介：
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
该基因编码的蛋白质可磷酸化真核生物翻译起始因子2的α亚基，导致其失活，从而引起翻译起始的迅速降低和全局蛋白质合成的抑制。该蛋白质被认为可以调节线粒体功能。它是一种位于内质网（ER）中的I型膜蛋白，在内质网应激下被诱导，而内质网应激则由错误折叠的蛋白质引起。人类中类似基因的突变与Wolcott-Rallison综合征相关。[由RefSeq提供，2015年9月]
提供机构：
Rat Genome Database
