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DNA microarray analysis in hippocampus of Wild-type (WT), AtrxΔE2, and TMPyP4-treated AtrxΔE2 mice.

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103032
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TMPyP4 treatment antagonizes cognitive deficits seen in ATR-X model (AtrxΔE2) mice. Our findings suggest a potential therapeutic strategy to target G-quadruplexes and decrease cognitive impairment associated with ATR-X syndrome. We administered TMPyP4 (30mg/kg, i.p.) to AtrxΔE2 mice twice weekly between post-natal day 30 to 90. (n = 5 mice per group per pool)
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2021-07-25
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