SINGLE CELL ANALYSIS OF THE HUMAN PLACENTA

Pregnancy and parturition is a complex physiological process requiring a well-orchestrated dialogue between the mother and fetus. The samples collected in this study aim to elucidate using single cell genomics the cellular mechanisms and molecular communications that facilitate maternal-fetal crosstalk during pregnancy and in labor both in healthy and pathological conditions. Samples from previous versions (#1-3) of this study include the placental villous tree, basal plate, and chorioamniotic membranes of women across a range of pregnancy physiologic and pathologic conditions, including the processes of labor (term labor and preterm labor), and COVID-19 (version #3). Version #4 includes samples from the human myometrium during spontaneous term labor. Version #5 focused on deciphering... (for more see dbGaP study page.)