Photocatalyzed/base-mediated defluorinative three-component cascade cyclization: Access to monofluorocyclohexenes and 6-fluoro-1,2,3,4-tetrahydropyridines

A three-component cascade cyclization of α-CF3 alkenes, electron-rich
alkenes, and dimethyl esters or sulfonamides via a dual C-F bond cleavage
process is described. This methodology provides a general and efficient
strategy to access monofluorocyclohexenes and
6-fluoro-1,2,3,4-tetrahydropyridines by switching the bifunctional
reagents (dimethyl esters or sulfonamides), which are valuable building
blocks in synthetic chemistry and the pharmaceutical industries. The
reaction mechanism and the synthetic applications of the products have
been demonstrated.