HRD analysis of the ovarian cancer
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https://www.ncbi.nlm.nih.gov/sra/SRP388907
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资源简介：
Homologous recombination (HR)-mediated DNA repair is a prerequisite for the maintenance of genome stability. Cancer cells with HR deficiency (HRD) are selectively and significantly eliminated by poly (ADP-ribose) polymerase inhibitors (PARPi), which benefit the survival rate of cancer patients, including breast, ovarian, pancreatic, and prostate cancers. To date, sequencing the pathogenic mutations in HR-associated BRCA1/2 genes and analyzing the genomic scar derived from genome instability have been used as the clinical biomarker for the treatment of PARPi.
创建时间：
2022-11-12
