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Genome resilience safeguards functional chromatin states - Part2
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2024-05-28
相关数据集
Histone H3.3 maintains genome integrity during mammalian development
Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans, and has been implicated in many important biological processes including cell differentiation and reprogramming. Germlin
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BLM prevents instability of structure-forming DNA sequences at common fragile sites
Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved is not well
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Integrating RNA-seq and assay for transposase-accessible chromatin by sequencing (ATAC-seq) predicts functionally-relevant chromatin regions
Gene regulation is critical for proper cellular function. Next-generation sequencing technology has revealed the presence of regulatory networks that regulate gene expression and essential cellular fu
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Expansions and Contractions in a Tandem Repeat Induced by Double-Strand Break Repair
Repair of a double-strand break (DSB) in yeast can induce very frequent expansions and contractions in a tandem array of 375-bp repeats. These results strongly suggest that DSB repair can be a major s
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Effect of plastid transcription on genome integrity in Arabidopsis
Transcription can be an important natural source of genome instability. For instance, it may generate RNA:DNA hybrids as the nascent transcript hybridizes with the complementary DNA template. These hy
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