Functional and structural characterisation of perforin antibodies
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This thesis investigates the properties of a panel of novel antibodies with a high affinity and efficacy toward a vital component of T cell cytotoxicity, perforin, which are generated from chicken libraries. X-ray crystallography determines the structures of antibodies in complex with perforin and on their own. This study explores the therapeutic potentials of antibody inhibitors targeting perforin-induced diseases.
创建时间：
2023-09-22
