Adoptive transfer of type 2 diabetes by hematopoietic stem cells reprogrammed in utero by vitamin D deficiency

This study demonstrates that transplantation of fetal liver hematopoietic stem cells (FL-HSCs) from fetuses subjected to vitamin D (VD) deficiency in utero induced persistent insulin resistance to VD sufficient recipient mice. Transcriptional changes associated with intrauterine vitamin D deficiency where identified through microarray analysis of mouse BMMs from vitamin D deficient and sufficient conditions. Gene expression profiles of Vitamin D sufficent and deficient BMMs were comapared and pathway analysis performed.