S1 File - Acute Endovascular Reperfusion Therapy in Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Appendix A: PubMed search Strategy. Appendix B: Grading Quality of the Evidence and Recommendations. Table A: PRISMA Checklist. Table B: GRADE evaluation of quality of evidence. Table C: List of excluded studies. Figure A: Cumulative meta-analysis (i.e. effects over time). Figure B: Forest plots showing any intracranial hemorrhage between endovascular therapy and controls. Figure C: Forest plot showing mortality in endovascular therapy vs controls. Figure C1: IA thrombolysis only vs mechanical device use. Figure C2: Comparator includes IV thrombolysis vs no thrombolysis. Figure C3: Studies that required vessel occlusion vs studies did not require vessel occlusion status. Figure D: Forest plot showing any intracranial hemorrhage in endovascular therapy vs controls. Figure D1: IA thrombolysis only vs mechanical device use. Figure D2: Comparator includes IV thrombolysis vs no thrombolysis. Figure D3: Studies that required vessel occlusion vs studies did not require vessel occlusion status. Figure E: Forest plot showing symptomatic intracranial hemorrhage in endovascular therapy vs controls. Figure E1: IA thrombolysis only vs mechanical device use. Figure E2: Comparator includes IV thrombolysis vs no thrombolysis. Figure E3: Studies that required vessel occlusion vs studies did not require vessel occlusion status. Figure F: Funnel Plots and Egger’s test for asymmetry of the funnel plot (p<0.1 for asymmetry). Figure F1: Primary outcome: Rankin <3. Egger’s test: p value = 0.2. Figure F2: Secondary outcome: Mortality. Egger’s test: p value = 0.2. Figure F3: Secondary outcome: Any ICH. Egger’s test: p value = 0.03. Figure F4: Secondary outcome: Symptomatic ICH. Egger’s test: p value = 0.06. Figure G: Absolute risk differences (ARD) for the secondary outcomes. Figure G1: Mortality. Figure G2: Symptomatic ICH.
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