EmAtlas

Here, we developed the EmAtlas, which collects the most comprehensive multi-omics data and provides multi-scale tools to explore spatiotemporal activation during mammalian embryogenesis. EmAtlas contains data on multiple types of gene expression, chromatin accessibility, DNA methylation, nucleosome occupancy, histone modifications, and transcription factors, which displays the complete spatiotemporal landscape in mouse and human across several time points, involving gametogenesis, preimplantation, even fetus and neonate, and each tissue involves various cell types.本研究开发了EmAtlas数据库，该库收录了目前最为全面的多组学（multi-omics）数据，并配套提供多尺度分析工具，用于解析哺乳动物胚胎发生过程中的时空激活特征。EmAtlas涵盖基因表达、染色质可及性（chromatin accessibility）、DNA甲基化（DNA methylation）、核小体占据（nucleosome occupancy）、组蛋白修饰（histone modifications）及转录因子（transcription factors）等多类相关数据，完整呈现了小鼠与人类多个时间节点下的胚胎发育时空图谱，研究覆盖配子发生、植入前胚胎发育乃至胎儿与新生儿阶段，且各组织均包含多种细胞类型。

搜集汇总

背景与挑战

背景概述

EmAtlas是一个综合性的多组学图谱，旨在探索哺乳动物胚胎发生过程中的时空激活。它整合了小鼠和人类多个发育时间点的基因表达、表观遗传修饰和转录因子等数据，涵盖从配子发生到胎儿及新生儿阶段的多种组织和细胞类型。