gene expression in hippocampus from ophn1tim1Bill mouse males and controls during 24h

Oligophrenin1 X-linked Intelectual disability (ID) gene is mutated in ID patients with cerebellar hypoplasia. It encodes OPHN1 protein which has been shown to interact with Rev-erb alpha, a negative regulator of the circadian clock in cells (https://doi.org/10.1038/nn.2911) In this study, we searched fo gene expression differences in hippocampi from adult mouse ophn1 KO and controls during 24 hours. Three replicates were collected evey 6 hours for both genotype. Data from controls were analyzed and reported in http://dx.doi.org/10.1016/j.neuroscience.2015.08.066. Adult males were placed in dark room for 24 hours before the collection of the hippocampus every 6 hours . PCA allowed the exclusion of two time points in controls (t=0 and 12).