p38 Mapk signaling pathway

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

P38 MAPKs属于MAPK家族，它们可被多种环境压力和炎症细胞因子激活。通过Rho家族小GTPase成员（如Rac、Rho、Cdc42）传递的压力信号触发了该级联反应。与其他MAPK级联反应相似，膜近端成分是一个MAPKKK，通常是MEKK或混合谱系激酶（MLK）。该MAPKKK磷酸化和激活MKK3/5，即p38 MAPK激酶。MKK3/6也可直接由受凋亡刺激激活的ASK1激活。P38 MAK参与调控Hsp27和MAPKAP-2，以及包括ATF2、STAT1、Max/Myc复合体、MEF-2、ELK-1等转录因子，并通过激活MSK1间接调控CREB。