Analysis of altered lncRNA and mRNA expression profiles in the streptozotocin-induced diabetic rats compared to normal SD rats

Diabetes mellitus (DM) is one of the most common chronic diseases around the world, and diabetic peripheral neuropathy (DPN) is one of the most common complications of DM. We used microarrays to identify the differentially expressed lncRNAs and mRNAs in dorsal root ganglia (DRG) tissues from streptozotocin (STZ)-induced diabetic rats, taking normal SD rats as controls, and tried to find out the related genes which may be involved in the development of DPN.糖尿病（Diabetes mellitus, DM）是全球范围内最常见的慢性疾病之一，糖尿病周围神经病变（Diabetic Peripheral Neuropathy, DPN）是糖尿病最为常见的并发症之一。本研究采用微阵列芯片技术，对链脲佐菌素（STZ）诱导的糖尿病大鼠的背根神经节（DRG）组织中的差异表达长链非编码RNA（lncRNAs）与信使RNA（mRNAs）进行鉴定，并以正常SD大鼠作为对照，旨在探寻可能参与DPN发生发展的相关基因。