Epigenetic modification, as a distinctive therapeutic molecule for Parkinson's disease gene therapy.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disruption of cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor function in an animal model of PD. Overall design: RNA-seq, CUT&RUN, ATAC-seq and scRNA-seq experiment conducted on 6-OHDA-induced PD model with NDST3 treatment.