Expression data from differentially responsive Toll-like receptor 4 (Tlr4)-normal mice infected with respiratory syncytial virus (RSV)

In airway epithelial cells, Tlr4 mediates both innate and adaptive immune responses to viral pathogens through the surface fusion glycoprotein (RSV F), however the mechanism is not well characterized. We used microarrays to identify differential gene expression pathways induced by RSV infection. Tlr4-normal mice were infected intranasally with RSV19 (10^6 PFU) or vehicle. Lungs were collected at 1 and 5 days post infection for RNA extraction and hybridization on Affymetrix arrays.