Genome-wide binding of GATA2 in 3T3-L1 und C3H10T1/2 cells and expression profile of primary mesenchymal cells with ectopic GATA2 expression

The transcription factor GATA2 is required for the expansion and differentiation of hematopoietic stem cells. GATA2 is also expressed in mesenchymal cells and was implicated in the regulation of adipocyte differentiation. Here we investigated genome-wide binding of endogenous GATA2 in mesenchymal cell lines and investigated the transcriptional responses of GATA2 overexpression in primary mesenchymal stem cells. Genomic occupancy profiled by high throughput sequencing (ChIP-seq) in 3T3-L1 cells and C3H10T1/2 cells for GATA2.