Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
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下载链接：
https://figshare.com/articles/dataset/Synthetic_Studies_toward_the_Natural_Product_Tripartin_the_First_Natural_Histone_Lysine_Demethylase_Inhibitor/6977459
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资源简介：
An
efficient synthesis of dimethyl tripartin as a synthetic precursor
of natural product tripartin, the first natural specific inhibitor
of histone H3 lysine 9 demethylase KDM4, is described. The synthesis
of dimethyl tripartin was achieved in a six-step longest linear sequence
starting from commercially available 3,5-dimethoxy benzaldehyde with
21% overall yield, using ClTi(OiPr)3-mediated dichloromethine insertion as the key step.
创建时间：
2018-08-16
