High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer. High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer

To explore the potential mechanism of isoleucine anti-tumor, we performed transcriptome data analysis of LLC mouse tumor xenograft model. We then performed gene expression profiling analysis using data obtained from RNA-seq of tumor tissues in two groups (Control & Isoleucine). Overall design: Comparative gene expression profiling analysis of RNA-seq data for tumor tissue from mice treated with isoleucine or PBS.