Epigenetic changes predict molecular responses to _erulean induced pancreatitis (CIP).

Schematic representation of ChIP-seq data showing H3K4Me3 enrichment for (A) Ptgs2 and (B) Rpik3, which were uniquely enriched for H3K4Me3 in Mist1−/− tissue but exhibit no change in gene expression. Arrows indicate peak differences. Bars under the graph depict the extent of the genes. Graphs represent qRT-PCR on whole pancreatic tissue from untreated or four hours of _erulean treatment in wild type (WT) and Mist1−/− (M1-) mice (left; n = 3), or immediately after acinar cell isolation (n = 4; right).