Investigation of potential tumour suppressor or tumour promoter roles in cutaneous squamous cell carcinoma progression

Analysis of the combined dataset of normal skin, actinic keratosis and cutaneous squamous cell carcinoma (cSCC) previously submitted in (GSE45216) at genomic/transciptomic level. We identified potential cSCC driver genes significantly mutated and upregulated in cSCC relative to normal skin. RNA was extracted by laser capture microdissection from actinic keratosis (AK), normal Sun exposed skin (SE) and normal non-Sun exposed skin (NSE), for analysis using the Affymetrix HG U133 Plus 2.0 microarrays.