Virus-induced inflammatory gene networks underlying asthma exacerbations in vivo. Homo sapiens

Global patterns of gene expression was profiled in nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced exacerbation and 7-14 days later. Gene coexpression network analysis and prior knowledge was employed to reconstruct the wiring diagram of the underlying gene networks. Overall design: The study design consisted of paired samples obtained during the acute exacerbation and 7-14 days later from 16 asthmatic children.