Dataset for meta-analysis and metaregression of published outcomes data on definitive radiotherapy with or without chemotherapy for locally advanced cervical cancer in patients with contraindications to cisplatin

We performed a systematic review and meta-analysis to examine the treatment outcomes in patients with locally advanced cervical cancer with contraindications to cisplatin, that were managed with definitive radiotherapy with or without chemotherapy. We then performed a metaregression to examine the effects of clinical and treatment variables on outcomes.

We identified eligible studies and extracted relevant data using a standardized data extraction template.

Table 1 summarizes the characteristics of the population or subgroup (including the nature of contraindication to cisplatin) and the intervention groups (radiotherapy, brachytherapy, and/or chemotherapy regimens) per each eligible study.

Table 2 summarizes our assessment of the risk of bias for each study using templates that were based on the CASP Critical Appraisal Checklists.

Tables 3 and 4 summarize the outcomes (tumor response, survival, compliance rates, and toxicity) for each intervention group.

Table 5 consolidates numerical data from Tables 1, 3, and 4, suitable for meta-analyses and meta-regression.

Table 6 is a composite database that contains the main template used in the preparation of the other datasets for the proportional meta-analyses and metaregression, given the variables and outcomes of interest.

Table 7 is a composite database that contains the datasets used for the comparative meta-analyses.

Figures 1 to 5b are Forests plots for pooled outcomes according to the intervention categories.

Figures 6a to 6f are Forest plots for pooled outcomes according to the use or non-use of chemotherapy and nodal boost.

本团队对患有局部晚期宫颈癌且对顺铂具有禁忌症的患者的治疗方案及其疗效进行了系统评价和荟萃分析。研究内容包括在或不在化疗辅助下的确定性放射治疗。随后，我们对临床和治疗变量对疗效的影响进行了元回归分析。通过标准化数据提取模板，我们确定了符合条件的研究并提取了相关数据。表1概述了每项符合条件的研究中人群或亚组的特征（包括对顺铂禁忌症的性质）以及干预组（放射治疗、近距离治疗以及/或化疗方案）。表2根据基于CASP关键评估清单的模板，对每项研究的偏倚风险进行了评估。表3和表4总结了每个干预组的疗效（肿瘤反应、生存率、依从率和毒性）。表5综合了来自表1、3和4的数值数据，适用于荟萃分析和元回归分析。表6是一个综合数据库，包含用于准备其他数据集的主要模板，该模板针对感兴趣的变量和结果进行了比例荟萃分析和元回归分析。表7是一个综合数据库，包含用于比较荟萃分析的 datasets。图1至图5b展示了按干预类别汇总的疗效的森林图。图6a至图6f展示了根据化疗的使用与否以及淋巴结加量情况汇总的疗效的森林图。