Characteristics of patients with GBM at first recurrence.

Necrosis (+) and (-) indicate that the tumor showed, respectively, the presence or absence of expanding area of necrosis (see Fig. 2). M =  Male. F =  Female. Age  =  age at initial diagnosis in years. Initial Therapy  =  therapy given prior to first recurrence. Surgery  =  initial surgical procedure at the time of diagnosis. Chemo + Bev  =  chemotherapy given with bevacizumab. XRT  =  radiation therapy. Tem  =  Temozolomide. XRT/Tem  =  radiation therapy with concurrent Temozolomide. XRT, Tem  =  radiation therapy followed by Temozolomide. CCNU  =  Lomustine. CPT-11 =  Irinotecan. STR  =  subtotal resection. ICT-107 =  ICT-107 vaccine. Gliadel  =  Gliadel wafers. GTR  =  gross total resection. R =  craniotomy surgical details unknown. ** =  This patient had a diagnosis of gliosarcoma. The mean age of patients 1–11 is 48.4 years. The mean age of patients 12–23 is 54.7 years.
Characteristics of patients with GBM at first recurrence.