Tgfbr1

ENCODES a protein that exhibits ATP binding; protein serine/threonine kinase activity; protein-containing complex binding; INVOLVED IN animal organ regeneration; digestive tract development; embryo implantation; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH Carotid Artery Injuries; Experimental Liver Cirrhosis; Hyperalgesia; FOUND IN apical plasma membrane; basolateral plasma membrane; caveola; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine

编码一种具有ATP结合能力、丝氨酸/苏氨酸激酶活性以及蛋白质复合物结合能力的蛋白；该蛋白参与动物器官再生、消化系统发育、胚胎着床过程；在转化生长因子-βSmad依赖性信号通路中发挥作用，并涉及转化生长因子-βSmad依赖性信号通路的变化以及结直肠癌通路；与颈动脉损伤、实验性肝硬化和痛觉过敏相关；存在于顶侧质膜、基侧质膜、内陷小窝中；与(S)-尼古丁、17β-雌二醇和2,3,7,8-四氯二苯并-对-二恶英相互作用。